Benzene Exposure And Cancer Mechanism Of Toxicity And...

Benzene exposure and Cancer: Mechanism of Toxicity and Carcinogenesis Benzene is the simplest aromatic hydrocarbon that is represented with the formula C6H6. It was discovered in 1825 by a British scientist, Michael Faraday, who extracted it from crude oil by applying pressure, and named it â€Å"Bicarburet of hydrogen†. However, its chemical synthesis did not start until in 1843, Charles Mansfield, discovered a method to extract benzene from coal tar. Since its industrialization, benzene is produced and used in many industrial processes, for instance, the production of plastics, resins, and dyes uses benzene as solvent. Similarly, chemical synthesis of phenol, cyclohexane, ethylbenzene and other aromatic hydrocarbons creates benzene as part of their production. In 1989, the Environmental Protection Agency of USA estimates the national emission of benzene in a total of 34.000 metric tons/ year. (EPA 1989). Identically, in Canada, the national benzene emissions were reduced from 50.860 metric tons/year in 1995 to 14.560 metrics tons/year, mainly due to regulation by The Canadian Council of Minister of the Environment(CCME 2012). Most of the benzene’s occupational exposure occurs during solvent exposure, synthesizing other chemical compounds, and working at oil pipelines, tankers, gasoline pumper, auto repairs shops, and oil refineries (ATSDR 2007). In western countries, such as USA, Canada or the European Union, the occupational exposition to benzene are regulated. ForShow MoreRelatedMolecular Basis Of Biology And Biotechnology4394 Words   |  18 Pages14 3.7 Laboratory analysis of biochemical parameters 15 3.7.1 Liver function test 15 3.7.2 Lipid profiling. 15 3.8 Histopathological analysis: 16 3.9 Antioxidation Analysis: 16 4.0 Plant Functional Properties 16 5.0 Determination of Mechanism of Efficacy and Toxicity of Antidiabetic Compounds 17 5.1 RNA Preparation 17 5.2 Array Hybridisation and Scanning 17 5.3 Data Validation by Quantitative RT-PCR 18 6.0 Management and Processing of Bioassays Data 18 REFERENCES 19 APPENDICES 26 APPENDIX I: WorkRead MoreBhopal Gas Disaster84210 Words   |  337 Pagesliving in the vicinity of the factory are exposed to toxic chemicals that continue to leach from tonnes of waste lying within the UCIL premises causing groundwater and soil contamination. As a result a whole new generation continues to get sick, from cancer and birth defects to everyday impacts o aches and pains, f rashes, fevers, eruptions of boils, headaches, nausea, lack of appetite, dizziness, and constant exhaustion. During the last four years survivors’ organizations have renewed their campaign